Pasireotide (PAS) is a novel somatostatin receptor ligands (SRL), used in controlling hormonal hypersecretion in both acromegaly and Cushing’s Disease (CD). In previous studies and meta-analysis, first-generation SRLs were reported to be able to induce significant tumor shrinkage only in somatotroph adenomas.
We characterized the phenotype of a large cohort of patients with Cushing’s Disease, a rare condition associated with elevated cortisol levels. Results from hypercortisolemic patients with active Cushing’s were compared with those obtained from eucortisolemic patients after remission and from non-diseased volunteers.
In this CME Webinar, #endocrinology experts in the management of #CushingsDisease will describe best practices for the diagnosis and treatment to improve long-term outcomes for patients.
I'm on a medication which interferes with the dexamethasone suppression tests. I tried going off the medication, but wasn't able to do so. I've taken saliva and 24 urine tests. I have many of the symptoms. Has anyone experienced what I am going through?
Version 4.7.0 of Invision Community includes a security update We got a bunch of new features and It's going to look a little different but please let me know if anything is not working properly.
Subclinical pituitary hemorrhage, necrosis, and/or cystic degeneration (SPH) presents mainly in large tumors and prolactinomas. The characteristics of patients with Cushing disease (CD) and SPH are not known.
I am so thankful for all the friends and support I've been given through out my Cushing's journey. If it weren't for Mary Kelly O'Connor and the Cushing's Help and Suppot Boards, I wouldn't even know a BLA was an option to save my life.
Patients with Cushing’s syndrome (CS) represent a highly sensitive group during corona virus disease 2019 (COVID-19) pandemic. The effect of multiple comorbidities and immune system supression make the clinical picture complicated and treatment challenging.
Thank you so much, MaryO, for all your hard work and dedication to creating a safe space with integrity and so much unbiased and valuable information and support.
Cushing's syndrome (CS) shows diverse signs such as centripetal obesity, moon face, and buffalo hump, which can complicate the diagnosis. Facial features including eyelid edema, as an underrecognized sign, can be diagnostic clues for an excess of corticoids in a CS patient.
It’s unbelievable but the idea for Cushing’s Help and Support arrived 22 years ago late last night. I was talking with my dear friend Alice, who ran a wonderful menopause site called Power Surge, wondering why there weren’t many support groups online (OR off!) for Cushing’s and I wondered if I could start one myself and we decided that I could.
Lisa is from St. Louis Mo. In the last 9 months she has been in the ICU twice for adrenal crisis after three pituitary surgeries. Nothing is getting better.
Endoscopic endonasal surgery is the main transsphenoidal approach for pituitary surgery in many centers, however few studies compare the endoscopic and microscopic surgical approach with regard to long-term follow-up. This single-center study aimed to compare the two techniques over 15 years.
Cushing’s disease (CD) is among the most common etiologies of hypercortisolism. Magnetic resonance imaging (MRI) is often utilized in the diagnosis of CD, however, up to 64% of adrenocorticotropic hormone (ACTH)-producing pituitary microadenomas are undetectable on MRI. We report 15 cases of MRI negative CD who underwent surgical resection utilizing a purely […]
Kassey passed away on June 30, 2016. Her sister said she died in her sleep. She was in the hospital due to a crisis on June 21st. Kassey was only 20 years old.
Kim is from Wisconsin. She was recently diagnosed with Cushing’s after about three years of testing. This is in addition to a diagnosis of Lipedema a little over a year ago.
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