Sweet 16

September 30, 2000 - Birth of the Message Boards

September 30, 2000 – Birth of the Message Boards

 

Today  is the birthday, or anniversary, of the boards starting September 30, 2000 (The rest of the site started earlier that year in July)

As of today, we have 12,468 members who have made 381,418 posts.

Find the message boards here: http://cushings.invisionzone.com/

Pituitary Patient Support Group Meeting in Santa Monica, CA

patient-support-meeting

Pituitary Patient Support Group Meeting!
Saturday–November 19th, 2016
“We will be Live Streaming on Facebook!!!”

Speaker: Garni Barkhoudarian, MD
Topic: “Advancements in Pituitary Surgery-Better Treatments, Better Quality of Life”
Meeting: 10:00am-11:00am
Breakfast Snack will be served 10:00am-11:00am
Lunch will be served 11:30am following the meeting
Family and Friends Welcome!
Please RSVP: Sharmyn McGraw at pituitarybuddy@hotmail.com or message on FB

Adiponectin level may serve as predictor of subclinical Cushing’s syndrome

Unal AD, et al. Int J Endocrinol. 2016;doi:10.1155/2016/8519362.

 

In adults with adrenal incidentaloma, adiponectin levels may help predict the presence of subclinical Cushing’s disease, according to recent findings.

Asli Dogruk Unal, MD, of the department of endocrinology and metabolism at Memorial Atasehir Hospital in Istanbul, and colleagues analyzed data from 40 patients with adrenal incidentaloma (24 women; mean age, 61 years) and 30 metabolically healthy adults without adrenal adenomas or hyperplasia (22 women; mean age, 26 years). All patients with type 2 diabetes were newly diagnosed and not on any antidiabetic therapies; included patients were not using statin therapy for about 12 weeks.

Participants provided blood samples

Among patients with adrenal incidentaloma, eight (20%) were diagnosed with subclinical Cushing’s syndrome; median adenoma diameter in these patients was 3.05 cm. The remaining patients were classified as nonfunctional adrenal incidentaloma. Compared with patients who had nonfunctional adrenal incidentaloma, patients with subclinical Cushing’s syndrome had a higher median midnight cortisol level (9.15 µg/dL vs. 5.1 µg/dL; P = .004) and urinary free cortisol level (249 µg per 24 hours vs. 170 µg per 24 hours; P = .007).

In two group comparisons, researchers found that only adiponectin level was lower in the subclinical Cushing’s syndrome group vs. the nonfunctional adrenal incidentaloma group (P = .007); there were no observed between-group differences for age, BMI, waist circumference, insulin levels, homeostasis model assessment for insulin resistance (HOMA-IR) or lipid profiles.

Adiponectin level was negatively associated with insulin level, HOMA-IR, triglyceride level and midnight cortisol level, and was positively associated with body fat percentage, HDL and adrenocorticotropic hormone levels. In linear regression analysis, age was found to be an increasing factor, whereas sex, HOMA-IR, LDL, waist circumference and presence of subclinical Cushing’s syndrome were decreasing factors.

In evaluating the receiver operating characteristic analysis, researchers found that adiponectin level had a predictive value in determining the presence of subclinical Cushing’s syndrome (area under the curve: 0.81; 95% CI, 0.67-0.96). Sensitivity and specificity for an adiponectin value of 13 ng/mL or less in predicting the presence of subclinical Cushing’s syndrome were 87.5% and 77.4%, respectively; positive predictive value and negative predictive value were 50% and 96%, respectively.

“Presence of [subclinical Cushing’s syndrome] should be considered in case of an adiponectin level of 13 ng/mL in [adrenal incidentaloma] patients,” the researchers wrote. “Low adiponectin levels in [subclinical Cushing’s syndrome] patients may be important in treatment decision due to the known relation between adiponectin and cardiovascular events. In order to increase the evidences on this subject, further prospective follow-up studies with larger number of subjects are needed.” – by Regina Schaffer

Disclosure: The researchers report no relevant financial disclosures.

From http://www.healio.com/endocrinology/adrenal/news/in-the-journals/%7B81c38f07-b378-4ca1-806b-d5c17bea064c%7D/adiponectin-level-may-serve-as-predictor-of-subclinical-cushings-syndrome

Signs and Symptoms of Adult Growth Hormone Deficiency

Major Symptoms of Adult-Onset Growth Hormone deficiency

You may be wondering if the unusual symptoms you are feeling lately may be due to growth hormone deficiency. Growth hormone is now widely recognized as an important factor in the maintenance of health and well-being. However, research shows that most people won’t experience the debilitating effects of growth hormone deficiency during their lifetime as the condition is not a cause of aging but rather serious illness or injury. If you want to learn about growth hormone deficiency signs and symptoms and what clinics like the Nexel Medical can do about this problem, keep reading.

About growth hormone deficiency in children

Growth hormone deficiency manifests differently in childhood than it does in adulthood. For normal development, there needs to be an adequate amount of circulating growth hormones in the body. The main symptom of growth hormone deficiency in children is stunted growth and developmental problems. This is a result of insufficient amounts of this important hormone in the body that is normally secreted by the pituitary gland. The pituitary gland is a small gland located at the bottom of the hypothalamus, at the base of the brain. Any damage to the pituitary gland will cause a drop in growth hormone levels that could be dangerous for children.

Growth hormone deficiency in adults

Although it would be natural to assume that there is no need for a growth hormone in the body once the growth process is over and we’ve reached adult height and weight, this is simply not the case. The human growth hormone plays a vital role in overall health up until old age. Damage to the pituitary gland from tumors is the most common cause of growth hormone deficiency in adults. People also tend to experience a decline in growth hormone levels that naturally come with age, but researchers agree that this decline is insignificant and shouldn’t cause any problems. However, damage to the pituitary gland will definitely cause major symptoms that require immediate treatment from clinics such as the Nexel Medical. According to an article published in the Indian Journal of Endocrinology and Metabolism, growth hormone deficiency has been associated with abnormalities of:

  • Neuropsychiatric and cognitive functioning

  • Cardiovascular functioning

  • The neuromuscular system

  • The skeletal system

Metabolic functioning

All these problems can be significantly reversed with growth hormone therapy. Growth hormone is now widely recognized as a hormone playing a role in the regulation of body composition, energy levels, and normal mental functioning.

Causes and symptoms of growth hormone deficiency

According to current research, 65% of all cases of growth hormone deficiency are caused by pituitary tumors. Other common causes are infections of the pituitary gland, pituitary hemorrhage, and idiopathic growth hormone deficiency. Traumatic brain injury may also lead to growth hormone deficiency in some cases. The clinical features or signs and symptoms of growth hormone deficiency are many and may seem unspecific at first. Those suspecting problems with the pituitary gland and growth hormone deficiency should look out for the following:

  • Cognitive changes (memory, processing, speed, attention)

  • Mood changes (depression, anxiety)

  • Social withdrawal

  • Fatigue and lack of strength

  • Neuromuscular dysfunction

  • Decreased bone mineral density

  • Decreased sweating

  • Weight gain and muscle loss

  • Metabolic changes (insulin resistance, dyslipidemia)

  • Treatment of growth hormone deficiency

Growth hormone deficiency in adults is usually treated with growth hormone replacement therapy. The hormone is in such cases administered intravenously or through dermal implants. A study published in the Journal of Clinical Endocrinology and Metabolism found that administering growth hormone to patients with growth hormone deficiency resulted in a reduction of visceral body fat by 30%. The researchers also noticed an improvement in bone metabolism and a decline in psychiatric complaints in these patients.

Why growth hormone pills don’t work?

Taking oral supplements claiming to contain the human growth hormone won’t work simply because the majority of it will be digested by your gastrointestinal tract before it gets the chance to reach your bloodstream. This is mainly because the human growth hormone is a protein and all proteins are broken down by the digestive tract. This was confirmed by studies as stated in an FDA-published article explaining how growth hormone administered to dairy cows cannot affect humans.

Conclusion

The human growth hormone is an important hormone for the maintenance of health, metabolism, and mental functioning. Studies on growth hormone deficiency show that most people have adequate levels of this hormone in their bodies. Although a decline in growth hormone levels comes with age, this decline is not enough to cause major changes in a person’s health and well-being. On the other hand, structural damage to the pituitary gland will cause some of the major conditions and symptoms of growth hormone deficiency. In such cases, growth hormone replacement therapy is highly advised. Clinics such as Nexel Medical are among many that offer different hormone replacement therapies including for growth hormone deficiencies.

References

Hormone Replacement Therapy Clinic

http://www.ncbi.nlm.nih.gov/pubmed/23435439

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183535/

http://www.ncbi.nlm.nih.gov/pubmed/19001512

http://www.ncbi.nlm.nih.gov/pubmed/8432773

http://www.fda.gov/AnimalVeterinary/SafetyHealth/ProductSafetyInformation/ucm130321.htm

From http://theinscribermag.com/health-fitness/signs-and-symptoms-of-adult-growth-hormone-deficiency.html

“How can you leave her like this?”

A mother has revealed the anguish her family suffered after her daughter (16), who is in need of brain surgery, was turned away from Beaumont Hospital.

The National Centre for Neurosurgery had no beds or theatre access for nine patients with malignant brain tumours last Friday.
One of the people who was turned away was 16-year-old Chloe Holian from Donegal.

Her mother Caitriona explained to the Anton Savage Show on TodayFM that the road to treatment has been fraught with setbacks.

“I can’t stress how happy I am with the neurosurgeon and his team are there but it seems our consultant’s hands are tied, what am I supposed to do?” she said.

Chloe was diagnosed in July with a recurrence of Cushing’s syndrome, a metabolic disorder which is caused by abnormally high levels of the hormone cortisol in the blood stream.

After being promised treatment in July and then August, the Letterkenny girl was finally admitted on Thursday and was fasting for a procedure on Friday morning when she was told it was cancelled.

“When we got down they told us that they decided to put off the surgery for a couple of days,” said Caitriona.

She was told that the doctors wanted to perform a dexamethasone suppression test first to confirm that Chloe was, in fact, suffering from Cushing’s – despite previous diagnosis revealing that she was.

However, she soon found out that the test couldn’t be performed.

“At 11am someone in scrubs came around to say it wasn’t fair but he had to tell us she won’t be doing the surgery… and she wouldn’t be getting the major test either,” said Caitriona.

She said he was very empathetic of their situation.

“I felt sorry for him having to tell us that news… I asked him ‘how can you leave her like this?’

“He promised that he was going to organise this test himself. It was quite difficult as you need four people in the surgery to do this test, you need the radiographer, neurosurgeon, endocrinologist and anesthetist.”

Unfortunately, an anesthetist was not available for the test.

Caitriona said that Chloe was quite upset at the news. One of the side-effects of her condition is excessive weight gain and the student has gained six stone since last September.

“She had psyched herself up for the surgery,” explained her mother.

“Everybody was around her encouraging her, they threw a party for her before she went because it was a big thing. Chloe has no confidence because she’s put on an extra six stone. She was looking forward to getting her old self back, she just wanted to go and do this operation and get it over and done with.

“For anybody to have a little bit of a weight gain they can be conscious of it but if you’re 16-years-old and you’ve gained six stone and you can’t explain it…”

Caitriona said the family were forced to pack their bags and return to Donegal but, as of today, they have still not received a rescheduled appointment.

The mother-of-three is struggling to juggle home life with trips to Dublin but she said the family’s life is on hold until the tumour is removed.

This is the second time that Chloe has developed Cushing’s, in 2009 she was sent to London for surgery as treatment was not yet available in Ireland.

Patients lives are being threatened by delays, according to the head of the country’s national brain surgery centre. Clinical Director Mohsen Javadpour says people are at risk of dying while they’re waiting for treatment.

From http://www.independent.ie/life/how-can-you-leave-her-like-this-mothers-anguish-as-daughter-16-in-need-of-brain-surgery-is-turned-away-from-beaumont-35029557.html

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