Not only was central obesity the most common physical manifestation associated with hypercortisolism among these Cushing's disease patients, but it was also more frequently rated as severe at baseline
Our patient’s presentation was unusual as she presented at 40 years old, 10 years earlier than expected for PBMAH; and primarily with complaints of episodic blurry vision. Her symptoms also progressed rapidly as signs and symptoms largely presented over the course of 12 months, however responded well to surgical resection.
Literature regarding endogenous Cushing syndrome (CS) largely focuses on the challenges of diagnosis, subtyping, and treatment. The enigmatic phenomenon of glucocorticoid withdrawal syndrome (GWS), due to rapid reduction in cortisol exposure following treatment of CS, is less commonly discussed but also difficult to manage. We highlight the clinical approach […]
A worldwide, observational study of adults and adolescents with growth hormone deficiency (GHD) found long-term GH replacement was safe. These findings were published in the Journal of Clinical Endocrinology & Metabolism. … The most common all-cause adverse events included arthralgia (4.6%), peripheral edema (3.9%), headache (3.6%), influenza (2.8%), dep […]
A difference in peak postoperative plasma copeptin as an early marker to predict remission of CD was not consistently present, although the data point to the need for a larger sample size to further evaluate this. However, the utility of this test may be limited to those who develop neither DI nor SIADH postoperatively.
Research opportunity for Human Growth Hormone Deficiency caregivers of adolescent patients. This is a 75 min web-assisted phone interview, and the compensation is $125.
Sadly, we lost another Cushing’s patient on Friday, May 9, 2014. Melinda was a member of the Cushing’s Help message boards since Jun 24, 2007. She was only 25 and left behind a young son and many loving family members.
Our community will experience a single, brief period of downtime this week. The exact timing is not known as this is a rolling update. There will be no data loss and most communities will see a downtime window of less than 10 minutes.
He died of a presumed heart attack. September 19, 2015 he said ''I was diagnosed hypertensive way back when I was 20. The condition remained for years, and became more acute with my cushings pit tumor. I still have high blood pressure, partially teated with three meds. I'll have to consult my doc and see if this may also be an issue.'
Despite improved outcomes in recent years, increased mortality from CS persists. The causes of death highlight the need to prevent and manage co-morbidities in addition to treating hypercortisolism.
Osilodrostat is associated with rapid normalization of mean urinary free cortisol (mUFC) excretion in patients with Cushing disease and has a favorable safety profile, according to the results of a study published in the Journal of Clinical Endocrinology & Metabolism.
The popular website "How Stuff Work"s is doing a survey of all kinds of diseases and Cushing's is one of them! The idea is simple.✨ Everyone shares experiences with different treatments. StuffThatWorks automatically transforms these experiences into data about which treatments work best, and for whom. Share your information and help get the wo […]
'My name is Caroline and I dont post often but have met a few of you guys and read the board regularly, it has definitely been a godsend to cushies everywhere. The reason I am writing tonight is I have just received devastating information about a dear friend of mine, and a woman some of you may have met during testing. Her name is Kathryn Miller and sh […]
Today is the final day of the Cushing’s Awareness Challenge and I wanted to leave you with this word of advice… To that end, I’m saving some of what I know for future blog posts, maybe even another Cushing’s Awareness Challenge next year.
Today I am thankful for my dog, Mimi. She’s a beautiful dog, sweet, loving and usually very mild-mannered, but she’ll bark her head off whenever she hears someone in the driveway.
Tonight, she barked at potential trick-or-treaters and we have lots of candy left over. 🙂
I hope I’m not jinxing myself but today I am thankful that I haven’t had any migraines for a long time.
It’s not “just” not having migraines, but the fact that, should I get one, there’s nothing I can do about them anymore.
I used to get migraines quite often, a hormone thing probably. I spent lots of hours in a completely dark room, blocking out sound, trying to keep my head from pounding.
There was a long period of time that I had a migraine 6 days out of the week for several weeks. By accident, a friend asked me on a Monday if I had one that day and that started me thinking – why do I have them every day except Mondays? I figured out that it wasn’t a migraine at all but an allergy headache – I was allergic to the bath oil I was using Monday-Saturday. I gave that to my Mom and those headaches went away.
I still often get allergy headaches. Since my Cushing’s transsphenoidal pituitary surgery, I can’t smell things very well and I often don’t know if there’s a scent that is going to trigger an allergic reaction. In church and elsewhere, my Mom will be my “Royal Sniffer” and if someone is wearing perfume or something scented, she’ll let me know and we’ll move to a new location.
There’s a double whammy here – since my kidney cancer surgery my doctor won’t let me take NSAIDs, asperin, Tylenol, any of the meds that might help a headache go away. My only hope would be that coffee from Day Fourteen. And that’s definitely not usually enough to get rid of one of these monsters.
So, I am very thankful that, for the moment, I am headache/migraine free!
Today, and every day, I am thankful for coffee. Without it, I would have a daily headache and I’d have even less energy than I have now.
I first started drinking coffee when I had my first job as a waitress at a Hayes-Bickford in Boston, MA. This was a summer job. A bunch of my college friends had gotten an apartment near Fenway Park in Boston and most of us were waitresses in various places. Hayes-Bickford was marginally better than a dive.
I was fortunate that I was the youngest waitress at that Hayes-Bickford, so I got the best tips. This was a l-o-n-g time ago – I’d get out of work sometime after midnight, take the Boston subway alone to our apartment, with an apron full of my tips, mostly in jangly change. That could never happen any more! Even without the money, I still wouldn’t wander around the Boston Common area of Boston alone after midnight.
The food at HB wasn’t so great. Sometimes, a patron would order some type of meat and the chef would say we were out of it, to put gravy on whatever-we-had and tell the diner that it was what he had ordered. We were usually out of a lot of things.
But the coffee was good and I learned to drink it, lots of it, and black, something I still do today. If I could do the IV thing, I would!
I’ve had a long history with singing from the time I was a kid singing in the choir at my Dad’s church. In High School we had a great choir and it was the time before “political correctness” would have banned us from singing such wonderful classical music like Brahms’ German Requiem. In college, as a music major, there were choirs and when we finally got to our current home, I joined Sweet Adelines.
I was a member of Sweet Adelines for 10 years, before Cushing’s robbed me of that particular pleasure. SA takes lot of energy between rehearsals, performances, competitions, travelling. I just loved it but I couldn’t keep up.
For a few years, I belonged to a local woman’s group but even that got to be too much after a while. There wasn’t the travelling or the competitions but rehearsals and performances cut into that energy.
Last year, our choir director opened up the opportunity to sing for just the Christmas Cantata. No long term committment and only half the rehearsal time for about 10 weeks.
I hadn’t sung anywere outside my car for about 10 years but, with trepidation, I signed up. Because of my bell-ringing and work with children’s choirs, I knew most of the other choir members and that made it a LOT easier on shy-me.
Christmas came and singing with the choir and orchestra was just fantastic. There was the invitation to stay, to become a part of the choir for good but I had my Cushing’s Interviews on Thursday nights and I couldn’t see how I could work all this in.
Last spring the choir sang How Lovely Is Thy Dwelling Place from Brahms’ German Requiem and I was hooked. How could I not join?
So, I moved the interviews to Wednesday nights and Thursdays are free for choir rehearsals.