For Cushing’s: Tosoh Bioscience Launches the ST AIA-PACK DHEA-S Assay

Posted on March 7, 2012 by MaryO

Tosoh introduces the ST AIA-PACK DHEA-S Assay for use on Tosoh Automated Immunoassay Analyzers

South San Francisco, CA (PRWEB) March 06, 2012

Tosoh Bioscience, Inc. introduces the ST AIA-PACK DHEA-S assay for use on Tosoh automated immunoassay analyzers including the AIA-360, AIA-600 II, AIA-1800, AIA-2000 and the new AIA-900.

Utilizing Tosoh’s unit dose test cup reagent technology, ST AIA-PACK DHEA-S has an assay time of approximately 20 minutes. Single, unitized test cups require no pre-mixing, no pre-measuring and no on-board refrigeration. Dry reagent format ensures 90 day calibration stability for minimal waste and cost effective testing. Test cups are bar-coded for easy identification and inventory management.

ST AIA-PACK DHEA-S is designed for In Vitro Diagnostic Use Only for the quantitative measurement of dehydroepiandrosterone sulfate (DHEA-S) in human serum, heparinized or EDTA plasma. DHEA-S is used for the diagnosis of various diseases of the adrenal cortex, and is especially useful for the differential diagnosis of Cushing’s syndrome.

Concentrations of DHEA-S are often measured, along with other hormones such as FSH, LH, prolactin, estrogen, and testosterone, to help diagnose polycystic ovarian syndrome (PCOS) and to help rule out other causes of infertility, amenorrhea, and hirsutism. DHEA-S levels may be ordered to investigate and diagnose the cause of virilization in young girls and early (precocious) puberty in young boys.

ST AIA-PACK DHEA-S has been designed for a variety of clinical diagnostic applications including: Pediatric/Children’s Hospitals, Endocrinologist, GP, Reproductive and Metabolic Clinics.

Tosoh Bioscience, Inc. (TBI) provides highly sophisticated diagnostic systems for immunoassay and HPLC testing to doctor’s offices, hospitals and reference laboratories throughout the Americas. Based in South San Francisco, CA, TBI is a U.S. subsidiary of Tosoh Corporation which is headquartered in Tokyo, Japan. TBI is part of Tosoh Corporation’s Bioscience Division.

 

For the original version on PRWeb visit: www.prweb.com/releases/prwebTosoh/DHEAS/prweb9248342.htm

Read more: http://www.sfgate.com/cgi-bin/article.cgi?f=/g/a/2012/03/06/prweb9248342.DTL#ixzz1oTaQcBBo

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Cushing’s Will Be on Mainstream TV – tomorrow!

Posted on March 5, 2012 by MaryO

ABC’s World News Tonight is doing a story on Cushing’s syndrome.

We are very excited in that it has a chance to raise awareness of Cushing’s among the millions of viewers and potentially reach some people who haven’t yet been diagnosed.

A physician who is going to be interviewed for the segment, which is planned to air tomorrow, March 6, 2012!

Be sure to tune in… and record the segment?

 

Filed under: Cushing's, Interview | Tagged: , , , | Leave a comment »

Small cell carcinoma of the vagina causing Cushing’s syndrome by ectopic production and secretion of ACTH

Posted on March 5, 2012 by MaryO

Hope found this interesting info for us:

Small cell carcinoma of the vagina causing Cushing’s syndrome by ectopic production and secretion of ACTH: a case report.

K M Colleran, M R Burge, L A Crooks, R I Dorin

Department of Medicine, Albuquerque VA Medical Center and University of New Mexico School of Medicine, 87108, USA.

BACKGROUND: Small cell carcinomas of pulmonary or extrapulmonary origin are neuroendocrine tumors classically associated with ectopic hormone production, particularly ACTH secretion resulting in Cushing’s syndrome. However, ectopic Cushing’s syndrome has not previously been reported in the setting of small cell carcinoma of the vagina.

METHODS: A primary vaginal tumor with hepatic metastases was evaluated with light microscopy. Serum cortisol and plasma ACTH levels were evaluated by radioimmunoassay and immunoradiometric assay, respectively, during a standard high-dose (8 mg) overnight dexamethasone suppression test.

RESULTS: Vaginal small cell carcinoma with hepatic metastases was demonstrated. Electrolyte abnormalities, elevated cortisol and ACTH levels, and failure to suppress ACTH secretion during high-dose dexamethasone administration confirmed the diagnosis of ectopic ACTH syndrome.

CONCLUSIONS: This case report establishes a clinical association between vaginal small cell carcinoma and ectopic Cushing’s syndrome, confirming the neuroendocrine potential of this malignancy and features common to small cell neoplasms originating in other sites.

More information and citations here: http://lib.bioinfo.pl/pmid:9190988

 

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Have You Had A Cushing’s Recurrence? Please Help with This Video Project!

Posted on March 5, 2012 by MaryO

Trisha writes: 

Working on a new video with Beth G. as my partner. With Corlum now thrown in the mix, we want to compare the best treatment options for recurring cushings. We want to hear from you about weather you are glad you had a BLA? if you could do it over again, would you? If you had meds available, did you try them first? What challanges do you have on a regular basis because of BLA? Why would you not want a BLA? What do you hope to get out of having a BLA?

We are not looking for the medical side, just the human side. If you would like to participate, message both Beth and myself on the same message. If you have a webcam, we would like to include video into the video and set up an interview.

Remember, its all about Awareness!

 

Beth says:

I’m working on a questionnaire so that everybody can answer the same set of questions. Trisha or I will email it so you to fill out, so can anybody interested please send us your email address? We’re interested in you if: 

a) You’ve had a BLA
b) You’re considering a BLA
c) You’re a potential candidate but would never consider a BLA

PLEASE REMEMBER: Any information you provide related to a BLA will become public, so if you’re not willing to have your thoughts and answers shared with the public (meaning outside of this group in a video that will hopefully go viral on youtube!) then please don’t sign up to help with this project!

Feel free to ask us questions! Thanks!!

 

If you want to participate, please email Beth at icybluesnow@gmail.com

Thanks!

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