Cushing’s syndrome: Pituitary surgery alone is the preferred treatment to improve survival


No agreement has been reached on the long-term survival prospects for patients with Cushing’s disease. We studied life expectancy in patients who had received curative treatment and whose hypercortisolism remained in remission for more than 10 years, and identified factors determining their survival.


We did a multicentre, multinational, retrospective cohort study using individual case records from specialist referral centres in the UK, Denmark, the Netherlands, and New Zealand. Inclusion criteria for participants, who had all been in studies reported previously in peer-reviewed publications, were diagnosis and treatment of Cushing’s disease, being cured of hypercortisolism for a minimum of 10 years at study entry, and continuing to be cured with no relapses until the database was frozen or death. We identified the number and type of treatments used to achieve cure, and used mortality as our primary endpoint. We compared mortality rates between patients with Cushing’s disease and the general population, and expressed them as standardised mortality ratios (SMRs). We analysed survival data with multivariate analysis (Cox regression) with no corrections for multiple testing.


Today’s Bravelet Special

TODAY! Rosa Bracelets are 25% OFF with code: ROSA25. Ends at midnight!

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$10 from every item sold on this page will be donated to help raise awareness for Cushing’s Disease through the work of the Cushings Help family of websites.

For nearly 16 years we have provided information, support, RSS feeds, news, and education for people with Cushing’s or other endocrine problems, their friends and families. Cushing’s syndrome is a hormonal disorder caused by prolonged exposure of the body’s tissues to high levels of cortisol.


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Nominations for RareVoice Awards close July 31



Rare Disease Legislative Advocates is accepting nominations for the 5th Annual RareVoice Awards, a celebration to honor advocates and policy leaders who give rare disease patients a “voice” on Capitol Hill and in State government.

All nominees will be honored at the awards celebration at Arena Stage in Washington, DC on November 16, 2016 and Abbey award recipients will be announced live at the event.

To nominate a rare disease champion, please click here. You can nominate someone in the category of patient advocacy, government staff, or congressional staff.

Deadline to submit nominations is July 31, 2016.

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