CushieBlog

Cushing’s Help RSS Feed

• 📰 VIDEO: New Cushing’s, Acromegaly Drug Data Prominent at ENDO Annual Meeting
  In this video exclusive, Maria Fleseriu, MD, FACE, reviews the pituitary research presented at the annual meeting of the Endocrine Society in Atlanta. Among the hottest pituitary topics at the meeting, according to Fleseriu, were dilemmas in pituitary tumors and data for new drugs for Cushing’s syndrome.
• 🏞 Cushing's MemberMap
  Cushing's MemberMap
• ✍️ Carola B (Carola), Adrenal Bio
  Carola is from Santa Cruz, CA. On December 26, 2014 she went to a local urgent care clinic with pneumonia, confirmed by an x-ray, for which she was treated.  Carola received a phone call from the urgent care clinic a few days afterwards explaining that the radiologist had seen something unusual that needed further examination.   After numerous tests her susp […]
• 📰 Cushing’s Syndrome With Acute Psychosis
  A 22-year-old woman with a three-month history of an increase in appetite, binge eating, and weight gain. After two weeks of her initial symptoms, she started to have grandiose and persecutory delusions, auditory hallucinations, decreased need for sleep, agitation, irritability, and aggression
• ℹ️ Basics: Meds - Various Medications
  Medications which are sometimes used to treat Cushing's
• 📰Altered Hippocampal Volume and Functional Connectivity in Patients with Cushing's Disease
  Stress-related brain disorders can be associated with glucocorticoid disturbance and hippocampal alteration. However, it remains largely unknown how cortisol affects the structure and function of hippocampus. Cushing's disease (CD) provides a unique “hyperexpression model” to explore the effects of excessive cortisol on hippocampus as well as the relati […]
• In Memory: Thomas F. Zachman ~ 1950-2010
  Thomas “Tommy” F. Zachman, of Windsor, formerly of Toledo, Ohio, died suddenly and unexpectedly at University Hospital in Denver on June 3, 2010, complications of Cushing's Syndrome.
• 🖤 In Memory of Sherry Carlson ~ May 30, 2020
  Sherry passed away, naturally and peacefully in her sleep. She loved her community and we know how grateful she was to every one of her friends on here for the genuine love and support she’s received over the years.
• ❓How Do We Cope with Uncertainty During Testing?
  When I suggested cushings to my GP early this year, after stumbling upon info online, and linking the purple stretch marks, high blood pressure, weight gain, brain fog etc... I was told by the GP that cushings was EXTREMELY rare, and most often "only diagnosed in children". I fell apart and I felt defeated after genuinely thinking there might have […]
• 👍 Share Your Experiences with Cushing's
  Let’s keep the ball rolling: the more members in the community, the smarter the insights. We're about 1,468 contributors away from being able to tell which treatments were reported to work better for different subgroups with common aspects. ~~~ The popular website "How Stuff Work"s is doing a survey of all kinds of diseases and Cushing's […]
• ⭐️ Top Picks on the Message Boards updated May 28, 2022
  Top content from across the message boards, hand-picked by MaryO and the Cushing's community.
• 📰Sparrow Pharmaceuticals Presents New Clinical Trial Data Analyses on HSD-1 Inhibitor SPI-62 at the 24th European Congress of Endocrinology
  Clinical trial analyses focus on the human body’s homeostatic response to potent HSD-1 inhibition by SPI-62. Results highlight that urinary free cortisol is distinct from intracellular cortisol that causes symptoms in patients with Cushing’s syndrome or autonomous cortisol secretion.
• 📰 Withdrawal Study Details Effects of Levoketoconazole in Cushing's Syndrome
  Data presented at AACE 2022 detail levoketoconazole-specific effects observed among patients with endogenous Cushing's syndrome from the phase 3 LOGICS trial.
• 📰 Osilodrostat Improves Physical Manifestations of Hypercortisolism for Most Adults
  Osilodrostat is associated with improvements in physical manifestations of hypercortisolism and reductions in mean body weight and BMI in adults with Cushing’s syndrome, according to a speaker.
• 📰Crinetics Pharmaceuticals (CRNX) Reports Positive Top-line Results Including Strong Adrenal Suppression from CRN04894 Phase 1 Study
  ACTH is the key regulator of the hypothalamic-pituitary adrenal (HPA) axis controlling adrenal activation. It is regulated by cortisol via a negative feedback loop that acts to inhibit ACTH secretion. This feedback loop is dysregulated in diseases of excess ACTH. In Cushing’s disease, a benign pituitary tumor drives excess ACTH secretion even in the presence […]
• 📰Recurrent Metatarsal Fractures in a Patient With Cushing Disease
  A 39-year-old premenopausal woman presented to the orthopedic outpatient clinic with recurrent metatarsal fractures and no history of trauma. A metabolic bone disease was suspected, and after further evaluation by endocrinology services, Cushing's Disease was diagnosed.
• 📰Osilodrostat Resolves Most Physical Signs of Cushing's Disease
  Not only was central obesity the most common physical manifestation associated with hypercortisolism among these Cushing's disease patients, but it was also more frequently rated as severe at baseline
• 📰 Intermittent Blurry Vision: An Unexpected Presentation of Cushing’s Syndrome Due to Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH)
  Our patient’s presentation was unusual as she presented at 40 years old, 10 years earlier than expected for PBMAH; and primarily with complaints of episodic blurry vision. Her symptoms also progressed rapidly as signs and symptoms largely presented over the course of 12 months, however responded well to surgical resection.
• 📰 The Genomic Landscape of Corticotroph Tumors: From Silent Adenomas to ACTH-Secreting Carcinomas
  Corticotroph cells give rise to aggressive and rare pituitary neoplasms comprising ACTH-producing adenomas resulting in Cushing disease (CD), clinically silent ACTH adenomas (SCA), Crooke cell adenomas (CCA) and ACTH-producing carcinomas (CA).
• 📰 Glucocorticoid Withdrawal Syndrome following treatment of endogenous Cushing Syndrome
  Literature regarding endogenous Cushing syndrome (CS) largely focuses on the challenges of diagnosis, subtyping, and treatment. The enigmatic phenomenon of glucocorticoid withdrawal syndrome (GWS), due to rapid reduction in cortisol exposure following treatment of CS, is less commonly discussed but also difficult to manage. We highlight the clinical approach […]