S Meah, E Youssef, W White
Summary: Researchers conducted this study to determine the efficacy of stereotactic radiosurgery with CyberKnife for the treatment of recurrent pituitary adenoma. They concluded that stereotactic radiosurgery for recurrent/residual pituitary adenomas using CyberKnife appears to be relatively safe and effective when compared to conventional radiotherapy.
Methods:
- Included in this retrospective study were patients who underwent cyberKnife radiosurgery for recurrent or residual pituitary adenoma at Barrow Neurological Institute (n=48).
- Patients were followed for an average of 44 months.
- Thirty-three patients had non-functioning adenomas, 10 had acromegaly, and 5 had Cushing’s disease.
- Researchers analyzed the change in tumor size, hormonal function, and complication of therapy for each patient.
Results:
- Tumor resection operation was performed through either the transsphenoidal or transcranial approach before CyberkKnife treatment.
- All patients had either recurrence or residual mass in the cavernous sinus before CyberKnife treatment.
- The total irradiation dose ranged from 2100-4000 cGy in an average of 3-5 fractions.
- Slightly more than half of the patients (n=26, 54.2%) had smaller tumors at follow-up, while 22 (45.8%) had stable tumors.
- Visual acuity remained unchanged post-treatment.
- One patient developed radiation-induced temporal lobe necrosis.
- Four patients (8.3%) required hormonal replacement due to panhypopituitarism.
- Of the 15 patients with functioning adenoma, hormonal function improved in 12.
- Treatment failed in 1 patient with acromegaly, 2 patients with Cushing’s disease, and 1 patient with non-functioning adenoma.
Filed under: 25th Annual Congress of the American Association of Clinical Endocrinologists, Cushing's, Meetings and Conferences, Treatments | Tagged: 25th Annual Congress of the American Association of Clinical Endocrinologists, Acromegaly, CyberKnife, Pituitary adenoma, radiosurgery, recurrence | Leave a comment »
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