Cushing’s Help RSS FeedFrom the February, 2022 issue of Reader’s Digest:
Read the original article at readers-digest-misdiagnosed
Filed under: Cushing's, pituitary | Tagged: blood disorder, Cushing's, eyes, hair, Misdiagnosed, pituitary, pituitary tumor, Reader's Digest, skin, surgery, von Willebrand, warts, weight | Leave a comment »
In a case report published online January 19 in Pediatrics, iatrogenic Cushing’s syndrome (CS) is described in a 9-year-old girl who received topical ocular glucocorticoid (GC) treatment for bilateral iridocyclitis.
Daisuke Fukuhara, MD, PhD, from the Kyorin University School of Medicine in Mitaka, Japan, and colleagues present the case of a 9-year-old girl suffering from idiopathic uveitis. She arrived at the ophthalmology department with a complaint of painful eyes, and was diagnosed with bilateral iridocyclitis and started on betamethasone sodium phosphate eye drop treatment.
The authors note that the patient was referred to the pediatric department with stunted growth, truncal obesity, purple skin striae, buffalo hump, and moon face six months after initiation of topical ocular GC treatment. She was diagnosed with iatrogenic CS as her serum cortisol and plasma adrenocorticotropic hormone levels were undetectable. The clinical symptoms of CS were improved after the doses of topical ocular GC were reduced. On genetic analysis, the patient was found to have a single heterozygous nucleotide substitution in the 3′ untranslated region of the NR3C1 gene.
“However, additional investigations are required to determine if our findings can be extrapolated to other patients,” the authors write. “In conclusion, clinicians should be aware that even extremely low doses of topical ocular steroid therapy can cause iatrogenic CS.”
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Filed under: Cushing's, Rare Diseases, symptoms | Tagged: buffalo hump, Cushing's Syndrome, eye drops, eyes, iatrogenic, iridocyclitis, moon face, obesity, ocular glucocorticoid, striae | Leave a comment »
Dubai: A 34-year-old patient working as a crane operator has undergone a remarkable new procedure of surgery at Thumbay Hospital, Dubai, that facilitated the removal of a brain tumour through the nostrils.
The patient, Mehnaj Khan, a Pakistani crane operator, underwent endoscopic trans-nasal trans-sphenoidal surgery in September, where the tumour was removed through the nose by endoscopic surgery without any cut or stitches on the skin. The father of five children has now made a full recovery, with improved vision, a hospital spokesperson said.
Khan first noticed something was wrong when his eyesight began to diminish, first the right eye, followed by the left eye. Although he had ignored his frequent bouts of headache for two years, Khan was compelled to visit an ophthalmologist due to vision deterioration. When an eye check-up revealed nothing was wrong, he was referred to to Thumbay Hospital, where an MRI scan of the brain revealed that he had a large tumour in the pituitary gland, pressing on the optic apparatus of brain and also hypothalamus, a very vital part of brain. This tumour was pressing on his optic nerves, causing him to slowly lose his sight.
Dr. Ishwar Chandra Premsagar, consultant neurosurgeon at Thumbay Hospital who operated on Khan, said: “Conventionally, such operations require surgeons to open the skull — a procedure known as a craniotomy. Alternatively, affected portions of the brain are reached via major incisions in the side of the face or inside the mouth, leaving behind major scars of the surgery. However, the patient’s tumour was removed by suctioning it out through his nose.”
An ear nose and throat (ENT) surgeon and an eye surgeon were consulted to plan the surgery and save further deterioration of vision while providing a chance for complete recovery.
Khan, who was nearly blind in one eye with the tumour growth, expressed his gratitude to the hospital and the teams of surgeons as he noticed improvement in his vision after the surgery. By the end of the week, he could read too. The patient was very thankful to the team of surgeons.
Dr Premsagar added: “The endoscope provides a close-up view of the pituitary, allowing the surgeon to remove the entire tumour out in one go through the nostrils, causing no disfigurement or damage to the brain. On the other hand, the procedure ensures far less danger of brain damage or stroke, and the patient usually makes a quicker recovery. Although post-surgery, deterioration of vision stops, but one cannot guarantee complete recovery of vision. This patient was lucky as his vision improved, but it may not happen in all patients. Hence, it is extremely important that one should ensure early consultation, diagnosis and surgery to ensure high chances of recovery.”
From http://gulfnews.com/news/uae/health/uae-patient-s-brain-tumour-removed-through-nostrils-1.1933841
Filed under: pituitary, Rare Diseases, Treatments | Tagged: Dr. Ishwar Chandra Premsagar, Dubai, endoscopic, eyes, headache, hypothalamus, neurosurgeon, pituitary surgery, pituitary tumor, Thumbay Hospital, trans-nasal, transsphenoidal | Leave a comment »
Robin has made another excellent graphic of some of the symptoms of Cushing’s. There are far too many to be listed in any image, as shown by the list at http://www.cushings-help.com/toc.htm#symptoms
Just to be silly, a few years ago, I did my own version of Cushing’s symptoms:
Filed under: Cushing's, Cushing's Awareness Challenge 2014, FAQ, pituitary, Rare Diseases | Tagged: Actonel, aging, body, bones, buffalo hump, Calcium, Central Serous Retinopathy, checklist, children, corticosteroids, CSR, Cushing's Awareness, Cushing's Awareness Challenge 2014, depression, diabetes, Dr. David Cook, Dr. Mary Lee Vance, dry mouth, Eflornithine, eyes, Flutamide, graphic, growth hormone, hair, headache, heart, hGH, hirsuitism, infertility, men, miscellaneous, NIH, osteoporosis, pituitary tumors, prednisone, psychological, Robin, Rosacea, skin, sleep, soy, steroids, stress, symptoms, Vanqua, women, Zomacton | Leave a comment »
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